ASTM D8421
Standard Test Method for Determination of Per- and Polyfluoroalkyl Substances (PFAS) in Aqueous Matrices by Co-solvation followed by Liquid Chromatography Tandem Mass Spectrometry (LC/MS/MS)
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About This Item
ASTM D8421 is a test method for determining per- and polyfluoroalkyl substances (PFAS) in aqueous matrices by co-solvation followed by liquid chromatography tandem mass spectrometry (LC/MS/MS). It is designed to support analytical work where reliable PFAS measurement in water-based samples is needed for quality control, compliance, and environmental assessment. By pairing sample preparation with a targeted instrumental method, this standard helps users obtain more consistent results for PFAS-related testing.
What is ASTM D8421?
ASTM D8421 provides a standardized approach for measuring PFAS in aqueous matrices using co-solvation and LC/MS/MS. In practical terms, it describes a laboratory test method intended for water-based samples and related analytical workflows where PFAS determination is required. The standard’s value lies in giving users a common technical framework for preparing samples, separating target compounds, and detecting them with tandem mass spectrometry. As an ASTM standard, it supports repeatable testing practices and more comparable results across laboratories.
Where is ASTM D8421 used?
This standard is commonly used in laboratories that analyze water and other aqueous samples for PFAS content. It may be applied in environmental testing, quality assurance programs, and product or process evaluations where aqueous matrices must be screened or quantified for these substances. ASTM D8421 is also relevant to organizations that need a documented method for LC/MS/MS-based PFAS analysis and a consistent procedure for comparison between instruments, operators, or test sites.
Why is ASTM D8421 important?
ASTM D8421 matters because PFAS testing often requires careful, defensible analytical methods. A standardized test method helps improve consistency in laboratory results, supports procurement and compliance decisions, and reduces uncertainty when comparing data across different samples or testing programs. For organizations managing water-related materials or monitoring PFAS levels, the standard provides a clear technical basis for quality control and routine evaluation. ASTM D8421 can therefore help strengthen confidence in reported PFAS measurements.
- PFAS measurement in aqueous matrices
- Co-solvation sample preparation
- LC/MS/MS analytical workflow
- Standardized laboratory testing
- Support for quality and compliance work
- Publication Date: 2025-04-15
- Publisher: ASTM
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