ASTM D8587

ASTM D8587 is an ASTM guide for determining a point of departure (POD) or, when needed, assigning a threshold of toxicological concern (TTC) for use in a toxicological risk assessment of a non-cannabinoid ingredient intended for use in cannabinoid products for vaporization. It provides a technical framework for selecting a defensible value to support safety evaluation and exposure-based decision-making. ASTM D8587 is especially useful when a clear starting point is needed for assessing potential risk in a product-development or compliance workflow.

Purpose of ASTM D8587

The purpose of this guide is to help users identify an appropriate POD or, if necessary, apply a TTC approach for a non-cannabinoid ingredient in cannabinoid vapor products. In practice, this supports a structured toxicological risk assessment by giving a consistent way to organize available data and determine a suitable benchmark for evaluation. ASTM D8587 is intended to improve clarity and consistency when assessing ingredients where the toxicological basis must be documented and technically justified.

Common use cases of ASTM D8587

This standard is commonly used during ingredient screening, safety review, and risk assessment for formulations intended for vaporization. It may support technical teams evaluating whether a non-cannabinoid ingredient has enough toxicological information to establish a POD or whether a TTC value is more appropriate. ASTM D8587 is also relevant in product development, compliance review, and supplier qualification when a documented basis is needed for comparing ingredients and supporting internal safety decisions.

Why ASTM D8587 matters

ASTM D8587 matters because it helps create a more consistent and defensible approach to toxicological assessment. For organizations working with cannabinoid vapor products, it can support better documentation, reduce uncertainty in ingredient evaluation, and improve consistency across testing and review processes. Using ASTM D8587 may also help streamline procurement and quality-control decisions by giving stakeholders a shared technical reference for risk-based assessment of non-cannabinoid ingredients.

• POD selection guidance
• TTC assignment when needed
• Risk assessment support for vapor product ingredients
• Consistency in toxicological review
• Documentation for technical and compliance workflows