ASTM F2148
Standard Practice for Evaluation of Delayed Contact Hypersensitivity Using the Murine Local Lymph Node Assay (LLNA)
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About This Item
ASTM F2148 is a technical standard for evaluating delayed contact hypersensitivity using the Murine Local Lymph Node Assay (LLNA). It provides a structured way to assess whether a material or substance may trigger a delayed skin response, helping support safer product evaluation and informed compliance decisions. By focusing on a repeatable testing approach, this ASTM standard is useful for laboratories and quality teams that need a consistent method for biological hazard screening and comparative assessment.
What is ASTM F2148?
ASTM F2148, titled Standard Practice for Evaluation of Delayed Contact Hypersensitivity Using the Murine Local Lymph Node Assay (LLNA), describes a practice for assessing delayed contact hypersensitivity in a mouse model. The standard centers on the LLNA method, which is commonly used to examine potential sensitization responses under controlled test conditions. As a published ASTM standard, it supports a consistent technical framework for evaluation, reporting, and comparison of results when screening materials or formulations for possible skin sensitization concerns.
Where is ASTM F2148 used?
This standard is commonly used in laboratory testing programs that evaluate the skin sensitization potential of substances, formulations, or related materials. It is relevant wherever delayed contact hypersensitivity needs to be assessed using the Murine Local Lymph Node Assay. ASTM F2148 may support research, product development, regulatory testing, and internal quality workflows where biological response data are needed to help characterize a material before broader use or further validation.
Why is ASTM F2148 important?
ASTM F2148 matters because it helps create a more consistent and defensible approach to evaluating delayed contact hypersensitivity. Using a recognized standard can improve comparability across tests, support documentation for compliance, and reduce uncertainty in product evaluation decisions. For organizations that rely on toxicity or sensitization screening, the standard helps align testing practices with a defined method, which can strengthen quality control and risk management efforts.
- Murine Local Lymph Node Assay framework
- Delayed contact hypersensitivity evaluation
- Skin sensitization screening support
- Consistent laboratory test practice
- Product and material assessment aid
- Publication Date: 2019-02-07
- Publisher: ASTM
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